QuantiFERON Gold Standard test

Sample Type: Blood

What Is Tested

This QuantiFERON-TB Gold Plus Test is a blood test designed specifically to detect the presence of M. tuberculosis bacteria (MTB). Unlike tests that detect antibodies, it focuses on measuring the cell-mediated immune (CMI) response, which involves T-cells. CMI is a crucial aspect of the body’s defense against certain diseases, indicating activation when detected. While most blood tests assess antibody production following exposure, the Tuberculosis Blood Test targets T-cells, which are essential for fighting bacterial infections. As a result, individuals who have received the bacillus Calmette-Guérin (BCG) TB vaccine or those infected with environmental mycobacteria typically yield negative results on this blood test.

Who Should Get Tested?

According to the Centers for Disease Control and Prevention (CDC), the following individuals should consider undergoing tuberculosis (TB) testing:

  • Individuals who have close contact with patients at risk for TB, such as those working in nursing homes.
  • People with compromised immune systems.
  • Those arriving in the United States from countries with a high prevalence of TB, including regions like Latin America, the Caribbean, Africa, Asia, Eastern Europe, and Russia.
  • Individuals who have been in contact with someone diagnosed with TB.
  • People who use illegal drugs.
  • Individuals experiencing symptoms of TB, such as fever, cough, and weight loss.
  • Healthcare professionals.

When Is The QuantiFERON Test Recommended?

The QuantiFERON test is advisable for individuals who have previously received the Bacillus Calmette–Guérin (BCG) vaccine or those who may find it challenging to return for a follow-up appointment to evaluate TB skin test reactions.

What To Expect During The QuantiFERON Test?

Initially, a blood sample is collected using a needle and tube. The sample is then analyzed in a laboratory, with the results subsequently communicated to your physician.
This test assesses an individual’s immune response to Mycobacterium tuberculosis, specifically detecting the secretion of interferon-gamma by white blood cells when exposed to the TB bacterial antigen.

How To Interpret QuantiFERON Test Results:

  • Positive: Suggests TB infection, prompting further investigations to determine whether the infection is active or latent. Additional assessments, such as physical examination and chest X-ray, assist in diagnosing the type of infection, guiding subsequent treatment plans.
  • Negative: Indicates that active or latent infection is unlikely.

How Often Should QuantiFERON Testing Occur?

You can repeat the test at any time.

What To Expect After The Test

After you provide your specimen, it generally takes few business days to process and release your test results. Your test results will be available in a clear and easy-to-read report. Independent physicians are available to discuss questions or concerns you may have regarding your results.

This test is a whole-blood assay called Interferon-Gamma Release Assays (IGRAs), which identifies the body’s immune response to M. tuberculosis, the bacteria responsible for tuberculosis (TB). While TB primarily affects the lungs, it can also target other organs like the spine, kidneys, and brain. It’s worth noting that not everyone infected with TB bacteria develops symptoms, resulting in two distinct TB-related conditions: latent TB infection (LTBI) and TB disease. Left untreated, TB disease can be fatal. However, it’s important to understand that this test cannot distinguish between LTBI and active TB disease.

LTBI refers to a state where individuals carry TB bacteria without displaying symptoms, which may progress to TB disease over time. TB disease occurs when TB bacteria overwhelm the immune system, leading to symptomatic illness. The Tuberculosis Blood Test detects the presence of M. tuberculosis and serves as an initial step in determining whether someone has LTBI or TB disease. Further testing may be necessary if the blood test shows a positive result.

$119.00

What To Expect After The Test
Preparation
Fasting is jot required for this test.

recomendation

How It Works At-Home

Buy a lab test

We come to your location to collect labs.

Book blood draw date

No doctor visit is required. Book a visit with us to have your labs collects.

Get fast results

Some days appointments.

How It Works

In-Person blood draw

Buy a lab test

We come to your location to collect labs.

Schedule a blood draw

No doctor visit is required. Book a visit with us to have your labs collects.

Get fast results

Some days
appointments.